System and method for analysis of peptide synthesis fidelity
US10641778B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 10, 2016 |
| Grant date | May 5, 2020 |
| Priority date | — |
| Expiry date | Oct 10, 2037 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00725
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a system and method for assessing the fidelity of a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a plurality of binder sequences. A first amino acid is at a defined position within a first one of the binder sequences, and the population of peptide features includes a first control peptide feature synthesized to have an amino acid sequence including the first one of the binder sequences. The system and method further includes detecting a signal output characteristic of an interaction of the receptor with the first control peptide feature. The signal output is indicative of the fidelity of incorporation of the first amino acid into the first control peptide at the defined position within the first one of the binder sequences.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.