Method of preparing biologically formulations active

US10646444B2 · kind B2 · utility

Assignee

• Nortec Development Associates, Inc. · US

Inventors

• Orapin P. Rubino · Towaco, US
• David M. Jones · Ramsey, US
• Frank Bretschneider · Radeberg, DE
• Peter Frankhauser · Ettingen, CH
• Armin Prasch · Glückstadt, DE

Key dates

• Filing date: Apr 7, 2016
• Grant date: May 12, 2020
• Expiry date: Apr 7, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/4402
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides pellet for use as a core for a pharmaceutical dosage form having an inner and an outer zone where the inner zone includes a biologically active agent and said outer zone includes a layer formed by applying a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water. The invention also provides a process for making pharmaceutical pellets where the core or at least one a layer on the core is formed by (a) contacting powder particles, adhering them to each other and compacting the adhered pellets by a rolling movement, wherein the degree of densification is controlled by the rolling movement; and (b) feeding a sufficient amount of a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water to provide on said particles an outer zone including a layer formed from said substantially dry, free flowing inert powder.