Methods and compositions for CNS delivery of arylsulfatase A
US10646554B2 · kind B2 · utility
0Cited by
12References
19Claims
0Family size
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Key dates
| Filing date | Aug 23, 2017 |
| Grant date | May 12, 2020 |
| Priority date | — |
| Expiry date | Oct 3, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y310/01001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.