Patterning of fragile or non-planar surfaces for cell alignment

US10646896B2 · kind B2 · utility

Assignee

• THE TRUSTEES OF PRINCETON UNIVERSITY · US

Inventors

• Jeffrey Schwartz · Princeton, US
• Joshua Spechler · Cherry Hill, US
• Romain Fardel · New York, US
• Kelly Lim · Princeton, US

Key dates

• Filing date: Jul 13, 2017
• Grant date: May 12, 2020
• Expiry date: Nov 5, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2535/10
• WIPO field: Surface technology, coating
• WIPO sector: Chemistry

Abstract

A construct that supports cell attachment and alignment including a substrate that is incompatible with photolithography conditions, containing a physical pattern in at least part of one surface, the physical pattern optionally bearing a coating of a metal alkoxide, oxide or mixed oxide-alkoxide thereon and a Self-Assembled Monolayer of Phosphonate (SAMP) covalently attached thereto, which phosphonate contains functionality adapted for cell binding. The construct optionally also contains cells attached thereto. Also disclosed are methods of preparing such a construct.