Catalytic hydrogenation of substituted cyanopyridines and process for preparing substituted pyridylmethylbenzamides

US10647674B2 · kind B2 · utility

Assignee

• BAYER CROPSCIENCE AKTIENGESELLSCHAFT · DE

Inventors

• Wahed Ahmed Moradi · Monheim, DE
• Gunter Schlegel · Liederbach, DE
• Albert Schnatterer · Leverkusen, DE
• Frank Volz

Key dates

• Filing date: Apr 26, 2016
• Grant date: May 12, 2020
• Expiry date: Apr 26, 2036

Classification

• Technology area (CPC —): General

Abstract

The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.