Tetrahydroisoquinoline derived PRMT5-inhibitors
US10647708B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Sep 3, 2015 |
| Grant date | May 12, 2020 |
| Priority date | — |
| Expiry date | Sep 3, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of formula (I) wherein: R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.