Cysteine protease inhibitors and uses thereof

US10647709B2 · kind B2 · utility

Assignees

• The Trustees of Columbia University in the City of New York · US
• The Board of Trustees of the University of Illinois · US

Inventors

• Gregory R. Thatcher · Urbana, US
• Isaac Schiefer · Toledo, US
• Ottavio Arancio · New York, US
• Mauro Fa · New York, US

Key dates

• Filing date: Jun 24, 2016
• Grant date: May 12, 2020
• Expiry date: Jun 24, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides for methods for treatment of neurodegenerative diseases comprising administration novel cysteine protease inhibitors or compositions comprising novel cysteine protease inhibitors. In some embodiments, the cysteine protease inhibitors are calpain inhibitors.