Methods of controlling the formation of disulfide bonds in protein solutions
US10647777B2 · kind B2 · utility
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31Claims
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Key dates
| Filing date | Mar 25, 2015 |
| Grant date | May 12, 2020 |
| Priority date | — |
| Expiry date | Dec 26, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.