Microbial strain improvement by a HTP genomic engineering platform

US10647980B2 · kind B2 · utility

Assignee

• Zymergen Inc. · US

Inventors

• Zach Serber · Sausalito, US
• Erik Jedediah Dean · Lafayette, US
• Shawn Manchester · Oakland, US
• Katherine Gora · Berkeley, US
• Michael Flashman · Eureka, US
• Erin Shellman · Seattle, US
• Aaron Kimball · San Francisco, US
• Shawn Szyjka · Martinez, US
• Barbara Frewen · Alameda, US
• Thomas Treynor · Berkeley, US
• Kenneth S. Bruno · Walnut Creek, US

Key dates

• Filing date: Jul 1, 2019
• Grant date: May 12, 2020
• Expiry date: Jul 1, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2035/1058
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.