Raman cluster tagged molecules for biological imaging

US10648026B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Jingyue Ju · Englewood Cliffs, US
• Shiv Kumar · Montgomery, US
• Mirkó Palla · Newton, US
• James J. Russo · New York, US

Key dates

• Filing date: Mar 14, 2014
• Grant date: May 12, 2020
• Expiry date: Aug 10, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N21/658
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention provides nucleoside polyphosphate analogs each of which comprises a tag comprising a plurality of Raman-scattering moieties; compounds comprising said nucleoside polyphosphate analogs; and methods for determining the sequence of a single-stranded DNA or RNA using said nucleoside polyphosphate analogs. This invention also provides methods for detecting the interaction of a plurality of predetermined compounds, at least one of which having attached thereto a tag comprising a plurality of Raman-scattering moieties.