Patent · US Active

Production of dosage forms comprising a solid dispersion of a microcrystalline agent

US10653625B2 · kind B2 · utility

0Cited by

2References

13Claims

0Family size

Assignee

Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

Jörg Rosenberg · Ellerstadt, DE
Markus Mägerlein · Mannheim, DE
Bernd Liepold · Dossenheim, DE
Jorg Breitenbach · Mannheim, DE

Key dates

Filing date	Feb 9, 2006
Grant date	May 19, 2020
Priority date	—
Expiry date	Oct 6, 2029

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K9/145
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method is described for the production of dosage forms, which comprise a solid dispersion of a microcrystalline active substance, in which a thermoplastic polymer with a glass transition temperature Tg of at least 40° C. is melted and an active substance is dissolved homogeneously in the melt; crystallization of the active substance is initiated in the mass obtained; and the mass is cooled. Crystallization of the active substance can be initiated by adding a nonsolvent, seed crystals of the active substance or a derivatization reagent. In addition, crystallization can be initiated by holding the mass for a sufficient length of time at a temperature that is below the temperature at which the active substance is completely soluble in the mass.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.