Patent · US Active

Small molecule inhibitors of USP1 deubiquitinating enzyme activity

US10653676B2 · kind B2 · utility

2Cited by

18References

12Claims

0Family size

Assignees

DANA-FARBER CANCER INSTITUTE, INC. · US
The Brigham and Women's Hospital, Inc. · US

Inventors

Alan D'Andrea · Winchester, US
Gregory D. Cuny · Houston, US
Ross L. Stein · Sudbury, US
Marcie Glicksman · Salem, US
April Case · Watertown, US
Jun Xian · Sharon, US
David Matthew Wilson · Harlow, GB
Min Huang · Chongqing, CN

Key dates

Filing date	Nov 3, 2016
Grant date	May 19, 2020
Priority date	—
Expiry date	Nov 3, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D405/06
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.