6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors

US10653711B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Tongfei Wu · Leuven, BE
• Dirk Brehmer · Glückstadt, DE
• Lijs Beke · Ekeren, BE
• An Boeckx · Herentals, BE
• Gaston Stanislas Marcella Diels · Turnhout, BE
• Ronaldus Arnodus Hendrika Joseph Gilissen · Beerse, BE
• Edward C. Lawson · Pipersville, US
• Vineet Pande · Vosselaar, BE
• Marcus Cornelis Bernardus Catharina Paradé · Eindhoven, NL
• Wim Bert Griet Schepens · Sint-Katelijne-Waver, BE
• Johannes Wilhelmus John F. Thuring · Ekeren, BE
• Marcel Viellevoye · Breda, NL
• Weimei Sun · North Wales, US
• Lieven Meerpoel · Beerse, BE

Key dates

• Filing date: Aug 25, 2016
• Grant date: May 19, 2020
• Expiry date: Sep 4, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound: Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5).