Method for producing RNA compositions

US10653768B2 · kind B2 · utility

Assignee

• CureVac Real Estate GmbH · DE

Inventors

• Thorsten MUTZKE · Reutlingen, DE
• Markus Kreuz · St. Micheln, DE
• Stefanie SEWING · Tübingen, DE
• Fabian Johannes EBER · Stuttgart, DE
• Wenke WAGNER · Reutlingen, DE
• Michael Sonntag · Odenthal, DE
• Michael Wiggenhorn · Munich, DE
• Katharina KOLLAND · Augsburg, DE

Key dates

• Filing date: Apr 13, 2016
• Grant date: May 19, 2020
• Expiry date: Aug 16, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.