Method for aromatic fluorination

US10654776B2 · kind B2 · utility

Assignee

• DOW GLOBAL TECHNOLOGIES LLC · US

Inventors

• Melanie S. Sanford · Ann Arbor, US
• Douglas C. Bland · Mason, US
• Patrick S. Hanley · Midland, US
• Megan A. Cismesia · Midland, US
• Sydonie D. Schimler · Ann Arbor, US

Key dates

• Filing date: May 2, 2017
• Grant date: May 19, 2020
• Expiry date: May 2, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J21/008
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where A is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.