Indole derivatives and uses thereof

US10654828B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• John Ryan Kerrigan · Wakefield, US
• Natalie Dales · Arlington, US
• George Scott Tria · Cambridge, US
• Daniel Steven Palacios · Cambridge, US
• Paul Gormisky · Brookline, US

Key dates

• Filing date: Jul 26, 2018
• Grant date: May 19, 2020
• Expiry date: Jul 26, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.