Deuterated 3-(4,5-substituted aminopyrimidine)phenyl derivatives and use thereof

US10654851B2 · kind B2 · utility

Assignee

• NANJING CHUANGTE PHARMACEUTICAL TECHNOLOGY CO., LTD · CN

Inventors

• Yongqiang Zhu · Shaoxing, CN
• Zhaogang Liu · Nanjing, CN
• Chao FENG · Nanjing, CN
• Shihe HU · Nanjing, CN
• Hao Chen · Columbia, US
• Enhe Bai · Nanjing, CN
• Jie Wang · Lake Bluff, US
• Jingmiao SHI · Nanjing, CN

Key dates

• Filing date: Sep 18, 2017
• Grant date: May 19, 2020
• Expiry date: Sep 18, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A type of deuterated 3-(4,5-substituted aminopyrimidine)phenyl derivatives and use thereof. The derivatives are compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds or salts thereof can be used for treatment or prevention of diseases or illnesses through certain mutant forms of epidermal growth factor receptors, inhibit the growth of various tumor cells effectively, and inhibit other proteases of EGFR and Her families, they can be used for preparing anti-tumor drugs.