Cytotoxic agents and conjugates thereof

US10654873B2 · kind B2 · utility

Assignee

• POLYTHERICS LIMITED · GB

Inventors

• Nareshkumar Jain · Ringoes, US
• Sanjeevani Ghone · Monmouth Junction, US
• Sean Wesley Smith · Wantage, US
• Ian Glassford · King of Prussia, US
• Sylvia Degrado · Scotch Plains, US
• Fu-An Kang · Collegeville, US
• Senzhi Zhao · Bensalem, US

Key dates

• Filing date: Sep 15, 2017
• Grant date: May 19, 2020
• Expiry date: Sep 15, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are novel maytansinoid compounds of general formula I. Also provided herein are conjugates comprising the compounds linked to a binding protein via a linker, and conjugating reagents comprising the compounds attached via a linker to at least one functional group capable of reacting with a binding protein. Also provided herein are pharmaceutical compositions comprising the compounds and conjugates, therapeutic methods and uses involving the compounds and conjugates, for example in cancer therapy, and novel synthetic processes.