β-hairpin peptidomimetics

US10654897B2 · kind B2 · utility

Assignee

• POLYPHOR AG · CH

Inventors

• Daniel Obrecht · Amriswil, CH
• Anatol Luther · Binzen, DE
• Francesca Bernardini · Hésingue, FR
• Peter ZBINDEN · Magden, CH
• Sophie Barthélémy · Folgensbourg, FR
• Alexander Lederer · Basel, CH

Key dates

• Filing date: Sep 29, 2015
• Grant date: May 19, 2020
• Expiry date: Oct 12, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Beta-hairpin peptidomimetics of the general formula (I), cyclo[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2] and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have Gramnegative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.