Patent · US Active

Hyperbranched polyglycerol-coated particles and methods of making and using thereof

US10660828B2 · kind B2 · utility

1Cited by
6References
24Claims
0Family size

Assignee

Inventors

Key dates

Filing dateSep 19, 2016
Grant dateMay 26, 2020
Priority date—
Expiry dateSep 19, 2036

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K2800/624
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.