Pyridyl substituted indole compounds

US10660877B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Alaric J. Dyckman · Lawrenceville, US
• Dharmpal S. Dodd · Princeton, US
• Tasir Shamsul Haque · Yardley, US
• Louis J. Lombardo · Montgomery, US
• John E. Macor · Guilford, US
• Christopher P. Mussari · Princeton, US
• Laxman Pasunoori · Warangal, IN
• Michael A. Poss · Lawrenceville, US
• Sreekantha Ratna Kumar · Bengaluru, IN
• Shoshana L. Posy · Highland Park, US
• David R. Tortolani · Skillman, US
• Brian K. Whiteley · Lebanon, US
• Ramesh Kumar Sistla · Bengaluru, IN
• Subramanya Hegde · Kanchinakote, IN
• Anupama Kandhi Ramachandra Reddy · Chitradurga, IN

Key dates

• Filing date: Sep 8, 2017
• Grant date: May 26, 2020
• Expiry date: Sep 8, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula (I) N-oxide, or salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.