Polymorphic form of compound, preparation method and use thereof

US10662198B2 · kind B2 · utility

Assignee

• QILU PHARMACEUTICAL CO., LTD. · CN

Inventors

• Jianwei Shen · Lake Bluff, US
• Jin Zhang · Mountain View, US
• Long Li · Nanhu, CN
• Yonghong Gao · Shandong, CN
• Zhantao Zhang · Shandong, CN
• Yong Zhang · Sichuan, CN

Key dates

• Filing date: Apr 26, 2018
• Grant date: May 26, 2020
• Expiry date: Apr 26, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to polymorphic forms of the compound methyl (3R,6S)-6-amino-sulfonylamino-1-(thiazol-2-yl)-3-(2,3,4-trifluorophenyl)-3,5,6,7-tetrahydropyrrolo[1,2-c]pyrimidin-4-formate (compound 1). The present disclosure further relates to a pharmaceutical composition and pharmaceutical use and a preparation method of the polymorphic forms of compound 1.