Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone

US10662451B2 · kind B2 · utility

Assignee

• Genomatica, Inc. · US

Inventors

• Jun Sun · San Diego, US
• Mark J. Burk · Cambridge, GB
• Anthony P. Burgard · Bellefonte, US
• Robin E. Osterhout · San Diego, US
• Wei Niu · San Diego, US
• John D. Trawick · San Diego, US
• Robert Haselbeck · San Diego, US

Key dates

• Filing date: May 4, 2018
• Grant date: May 26, 2020
• Expiry date: May 4, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P7/18
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.