Peptides, compositions comprising them and uses in particular cosmetic uses

US10668000B2 · kind B2 · utility

Assignee

• Sederma · FR

Inventors

• Olivier Peschard · Rambouillet, FR
• Anne Doucet · Rambouillet, FR
• Richard Leroux · Faverolles, FR
• Philippe Mondon · Donneville, FR

Key dates

• Filing date: May 21, 2015
• Grant date: Jun 2, 2020
• Expiry date: Aug 2, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2800/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The peptides have the general following formula: X-Pro*-Pro*-Xaa-Y in which: •Xaa is selected from Leucine (Leu, L), Arginine (Arg, R), Lysine (Lys, K), Alanine (Ala, A), Serine (Ser, S), and Aspartic acid (Asp, D); •At the N terminal end of the peptide, X is selected from H, —CO—R1 and —SO2—R1; •At the C terminal end of the peptide, Y is selected from OH, OR1, NH2, NHR1 and NR1R2; •R1 and R2 are, independently from each other, selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy and aryloxy group, that can be linear, branched, cyclic, poly-cyclic, non-saturated, hydroxylated, carbonylated, phosphorylated and/or sulfured, and which skeletum can comprise an heteroatom, in particular an O, S and/or N atom; •Pro* correspond to a Proline, an analogue or derivative thereof; •if X is H then Y is selected from OR1, NH2, NHR1 and NR1R2, and if Y is OH then X is —CO— or —SO2—R1; and the peptide hypoxanthine-Pro-Pro-Arg being excluded. The invention provides the use of the peptides of above formula I to stimulate the synthesis of the molecules constituting the dermal extracellular matrix, including collagen I and IV and elastin. A cosmetic treatment according to the invention includes…