Anti-CD89 cytotoxic complex

US10668147B2 · kind B2 · utility

Assignees

• Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V. · DE
• Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen · DE

Inventors

• Christoph Stein · Baltimore, US
• Radoslav Mladenov · Zürich, CH
• Bernhard Stockmeyer · Erlangen, DE
• Stefan Barth · Jena, DE
• Lea Christin Schenke · Holzgerlingen, DE
• Rainer Fischer · Monschau, DE

Key dates

• Filing date: Mar 25, 2015
• Grant date: Jun 2, 2020
• Expiry date: Apr 23, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Complexes suitable for targeting and killing a human target cell comprising a first polypeptide with a binding structure for binding the complex to the cellular surface receptor CD89 (e.g. with an anti CD89 antibody) presented on the cell surface of the human target cell and a second polypeptide comprising a toxic effector domain, preferably Pseudomonas exotoxin A); to nucleic acid molecules encoding said complexes, vectors, host cells containing the nucleic acids and methods for preparation and producing such complexes; compositions and methods for using said complexes for the treatment of diseases, in particular of cancer diseases like leukemia.