Methods to induce targeted protein degradation through bifunctional molecules
US10669253B2 · kind B2 · utility
12Cited by
10References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 22, 2018 |
| Grant date | Jun 2, 2020 |
| Priority date | — |
| Expiry date | Oct 22, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J43/003
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application provides bifunctional compounds which act as SMARCA2 and Ras protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of SMARCA2 and Ras through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to SMARCA2 or Ras. The application also provides compounds of Formula:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.