Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO
US10669273B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Apr 1, 2017 |
| Grant date | Jun 2, 2020 |
| Priority date | — |
| Expiry date | Apr 1, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention discloses the use of aza-tryptanthrin derivatives as an IDO1 and/or TDO inhibitors, and the derivatives are represented by the general Formula (I). The compounds represented by the Formula (I) have inhibitory effects on indoleamine-2,3-dioxygenase 1 (IDO1) and/or tryptophan-2,3-dioxygenase (TDO), and can be used for treating diseases having the pathological features of IDO1 and/or TDO-mediated tryptophan metabolism, including but not limited to tumors, autoimmune disease, infectious diseases, Alzheimer's disease, depression, anxiety.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.