Patent · US Active

Mps1 and KNL1 phosphorylation system

US10669320B2 · kind B2 · utility

0Cited by

11References

4Claims

0Family size

Assignee

THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

Ajit P. Joglekar · Ann Arbor, US
Pavithra Aravamudhan · Nashville, US

Key dates

Filing date	Nov 18, 2016
Grant date	Jun 2, 2020
Priority date	—
Expiry date	Nov 18, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/70
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are compositions and methods for the treatment of cancer by activating the spindle assembly checkpoint (SAC) in cells. In particular, dimerized Mps1 and Spc105/KNL1 constructs are provided as tunable activators of SAC, allowing for control of chromosome segregation accuracy and prevention of aneuploidies that are common in cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.