Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use

US10669347B2 · kind B2 · utility

Assignee

• Sutro Biopharma, Inc. · US

Inventors

• Christopher D. Thanos · Tiburon, US
• Leslie McEvoy · Mountain View, US
• Gang Yin · South San Francisco, US
• Kalyani Penta · Palo Alto, US
• Ramesh Baliga · Redwood City, US
• Sunil Bajad · Fremont, US
• Sonia Pollitt · San Mateo, US
• Chris Murray · Soquel, US
• Alex Steiner · San Francisco, US
• Avinash Gill · Emeryville, US

Key dates

• Filing date: Jun 23, 2017
• Grant date: Jun 2, 2020
• Expiry date: Jun 23, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are antibodies comprising non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use. The antibodies are useful for methods of treatment and prevention, methods of detection and methods of diagnosis.