Recombinant strain of Bacillus subtilis
US10669532B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 1, 2018 |
| Grant date | Jun 2, 2020 |
| Priority date | — |
| Expiry date | Aug 1, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y604/01001
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a recombinant strain of Bacillus subtilis, wherein pyruvate carboxylase BalpycA, glyceraldehyde-3-phosphate ferredoxin dehydrogenase gor, isocitrate NAD+ dehydrogenase icd, malate quinone dehydrogenase mqo, pyruvate ferredoxin oxidoreductase porAB and nitrogenase ferritin cyh are integrated and expressed in the recombinant strain. The invention also discloses use of the recombinant strain in fermentation production of acetylglucosamine. The recombinant Bacillus subtilis of the invention eliminates the central carbon metabolism overflow of the Bacillus subtilis and balances the intracellular reducing force, and the fermentation yield of acetylglucosamine is greatly improved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.