Production of DHA and other LC PUFAs in plants

US10669554B2 · kind B2 · utility

Assignees

• DOW AGROSCIENCES LLC · US
• DSM IP ASSETS B.V. · NL

Inventors

• Terence A. Walsh · Zionsville, US
• Daniel Gachotte · Indianapolis, US
• Ann Owens Merlo · Carmel, US
• Paul Gordon Roessler · San Diego, US
• James G. Metz · Longmont, US
• Scott Bevan · Indianapolis, US
• Jerry M. Kuner · Longmont, US

Key dates

• Filing date: Nov 29, 2017
• Grant date: Jun 2, 2020
• Expiry date: Jan 11, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/1288
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).