Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing

US10669566B2 · kind B2 · utility

Assignee

• Accelerate Diagnostics, Inc. · US

Inventors

• William Richards · Tucson, US
• Austin Ashby · Tucson, US
• Matthew Ketterer · Tucson, US
• Kevin Marshall · Tucson, US
• Josh Harrison · Tucson, US
• Matthew Mette · Marana, US
• Paul Richards · Tucson, US
• Wayne Showalter · Tucson, US
• Jasmin Cote · Keyano, CA
• Steven W. Metzger · Westminster, US
• Ken Hance · Tucson, US
• Meghan Mensack · Thornton, US
• Carlos Michel · Tucson, US
• Elke Allers · Tucson, US
• Dulini Gamage · Tucson, US
• Landon Prisbrey · Tucson, US
• Oleg Gusyatin · Tucson, US
• Alena Shamsheyeva · Tucson, US
• Ben Turng · Ellicott City, US
• Andrew Ghusson · Tucson, US
• Kurt Reinhardt · Tucson, US
• Phillip C. Halbert · San Francisco, US
• Solene Bourgeois · San Francisco, US

Key dates

• Filing date: Jun 13, 2018
• Grant date: Jun 2, 2020
• Expiry date: Jul 29, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2035/1032
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.