Tagged nucleotides useful for nanopore detection
US10669580B2 · kind B2 · utility
1Cited by
11References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 23, 2017 |
| Grant date | Jun 2, 2020 |
| Priority date | — |
| Expiry date | Mar 3, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6823
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure relates to compounds comprising a negatively-charged polymer moiety which is capable of entering a nanopore and upon entering a nanopore in the presence of positive ions results in an increased flow of the positive ions through the nanopore. The present disclosure provides methods of preparing the compounds and for their use as nanopore-detectable tags, in particular, for nanopore-based nucleic acid detection and sequencing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.