Systems and methods for clinical decision support

US10672514B2 · kind B2 · utility

Assignee

• Molecular Health GmbH · DE

Inventors

• Alexander Zien · Heidelberg, DE
• David Brian Jackson · Spanish Fork, US
• Martin Stein · El Granada, US
• Guillaume Taglang · Heidelberg, DE
• Stephan Brock · Weinheim, DE
• Alexander Picker · Heidelberg, DE
• Theodoros Soldatos · Heidelberg, DE
• Bernhard Sulzer · Heidelberg, DE

Key dates

• Filing date: Oct 1, 2013
• Grant date: Jun 2, 2020
• Expiry date: Oct 6, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G16H70/20
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present disclosure relates to systems and methods for bioinformatics and data processing. In particular, in a first aspect, the present disclosure relates to methods and systems for generating a personalized treatment guideline for a patient and for selecting a treatment for a patient. In another aspect, the present disclosure relates to methods and systems for selecting patients for a clinical trial of a treatment. The invention resolves cases in which patients have more than one “actionable” aberration by combining the patient-specific molecular information and the treatment-specific molecular information further with a clinico-molecular disease model, specifically a scoring of genes and/or proteins that represents several aspects of their involvement into the disease. In this way, treatments and patients can be prioritized that are most likely to impact or impacted by the disease mechanism, respectively.