Method and apparatus for transdermal in vivo measurement by Raman spectroscopy
US10674919B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 24, 2015 |
| Grant date | Jun 9, 2020 |
| Priority date | — |
| Expiry date | Oct 13, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/14551
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The use of a transdermal Raman spectrum to measure glucose or other substance concentration can give an inaccurate result if the Raman signals originate at a wrong skin depth. To predict whether a spectrum of Raman signals received transdermally in a confocal detector apparatus and having at least one component expected to have an intensity representing the concentration of glucose or another skin component at a point of origin of the Raman signals below the surface of the skin will accurately represent the concentration, peaks in the spectrum at 883/4 cm−1 and 894 cm−1 are measured to determine whether the Raman signals originate primarily within the stratum corneum so that the spectrum will be less likely to represent the concentration accurately or originate primarily below the stratum corneum so that the spectrum will be more likely to represent the concentration accurately.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.