Antiproliferative compounds and methods of use thereof

US10675281B2 · kind B2 · utility

Assignee

• CELGENE CORPORATION · US

Inventors

• Matthew D. Alexander · San Diego, US
• Gerald D. Artman, III · Asbury, US
• Matthew D. Correa · San Diego, US
• Joshua Hansen · Village of La Jolla, US
• Xiaoling Lu · Whippany, US
• Hon-Wah Man · Princeton, US
• Mark A. Nagy · San Diego, US
• Paula A. Tavares-Greco · Parsippany, US
• Brandon W. Whitefield · San Diego, US
• Nanfei Zou · Fanwood, US

Key dates

• Filing date: Jun 3, 2019
• Grant date: Jun 9, 2020
• Expiry date: Jun 3, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2300/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.