Dispersed mobile-phase countercurrent chromatography
US10675558B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 14, 2017 |
| Grant date | Jun 9, 2020 |
| Priority date | — |
| Expiry date | Feb 11, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/027
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A dispersed mobile-phase countercurrent chromatography system is described in which solutes are carried by a stream of dispersed mobile phase solvent through a column, or array of serially-connected columns, of stationary phase solvent with which the mobile phase solvent is immiscible. Solutes carried along by the stream of dispersed mobile-phase solvent will be equilibrated between the mobile-phase solvent and the stationary-phase solvent. Because the mobile-phase is dispersed into mini-droplets much smaller in diameter than the column of stationary phase, the enhanced surface/volume ratio of the droplets expedites countercurrent equilibration of different solutes between the mobile-phase solvent and the stationary-phase solvent in accordance with the distribution-coefficients of the solutes between the two solvents. As a result, a solute with a distribution coefficient that favors its dissolving in the stationary phase will be retarded in its migration through the columns compared to a solute with a distribution coefficient that favors its dissolving in the mobile phase. The different migration rates of different solutes bring about their chromatographic separation on the columns…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.