Patent · US Active

Method for producing (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile

US10676443B2 · kind B2 · utility

0Cited by

10References

7Claims

0Family size

Assignee

pH Pharma Co., Ltd. · KR

Inventors

Heiko Schirmer · Solingen, DE
Philipp Rubenbauer · Bensheim, DE
Birgit Keil · Düsseldorf, DE
Britta Olenik · Bottrop, DE

Key dates

Filing date	Apr 25, 2019
Grant date	Jun 9, 2020
Priority date	—
Expiry date	Apr 25, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a new and improved method for preparation of (4S)-4-[4-cyano-2-(methyl sulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile of formula (I), as well as the preparation and use of the crystal form (A) of (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile of formula (I).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.