N-(3-heteroarylaryl)-4-arylarylcarboxamides and analogs as hedgehog pathway inhibitors and use thereof

US10676468B2 · kind B2 · utility

Assignee

• IMPACT THERAPEUTICS, INC. · CN

Inventors

• Suixiong Cai · 安丰镇, CN
• Ye Tian · Bloomington, US
• Sishun Kang · 安丰镇, CN
• Zheng Meng · 安丰镇, CN
• Chengyun Gu · 安丰镇, CN
• Feng Yin · 安丰镇, CN
• Shengzhi Chen · 安丰镇, CN
• Yang Zhang · San Diego, US
• Xiuyan Zhang · 安丰镇, CN
• Hongqiang Fei · 安丰镇, CN
• Dongmei Wang · Beijing, CN

Key dates

• Filing date: Jul 19, 2013
• Grant date: Jun 9, 2020
• Expiry date: Apr 22, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are novel N-(3-heteroarylaryl)-4-arylarylcarboxamides and analogs thereof, represented by the Formula I: wherein C cyclic group, D1-D4, Q1, Q2, R5 are defined herein. Compounds having Formula (I) are hedgehog pathway inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of hedgehog activity, such as cancer.