Vaults engineered for hydrophobic drug delivery

US10676534B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Leonard H. Rome · Calabasas, US
• Daniel Buehler · Warsaw, US
• Heather D. Maynard · Los Angeles, US

Key dates

• Filing date: Oct 17, 2014
• Grant date: Jun 9, 2020
• Expiry date: May 7, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/24271
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compositions of vault complexes for use as delivery agents for hydrophobic and/or aqueous insoluble therapeutic compounds. In one aspect, provided herein is a vault complex comprising a modified major vault protein (MVP), wherein the modified major vault protein comprises a fusion peptide, wherein said fusion peptide is fused to the N-terminus of the major vault protein, and wherein said peptide provides enhanced sequestering of a hydrophobic and/or aqueous insoluble therapeutic compound within the vault complex.