Patent · US Active

Methods for non-covalent Fc-domain-containing protein display on the surface of cells and methods of screening thereof

US10676733B2 · kind B2 · utility

0Cited by

2References

24Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Laura Rhiel · Frankfurt am Main, DE
Stefan Becker · Darmstadt, DE
Ralf Guenther · Griesheim, DE
Bjoern Hock · Maintal, DE
Daniel Helman · Nahariah, IL
Mira Toister-Achituv · Rehovot, IL
Simon Krah · Darmstadt, DE

Key dates

Filing date	Oct 27, 2015
Grant date	Jun 9, 2020
Priority date	—
Expiry date	Apr 27, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC40B30/06
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides methods for the non-covalent surface display of proteins of interest (POI), in particular for Fc-domain containing proteins such as antibodies. The inventive method may be used to screen and select proteins of interest of a desired phenotype. The present invention further discloses polynucleotides and proteins and methods of producing the same, which may be used in carrying out the inventive method.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.