Targeted RNA editing
US10676737B2 · kind B2 · utility
10Cited by
0References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 17, 2015 |
| Grant date | Jun 9, 2020 |
| Priority date | — |
| Expiry date | Apr 3, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/533
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
RNA editing is achieved using oligonucleotide constructs comprising (i) a targeting portion specific for a target nucleic acid sequence to be edited and (ii) a recruiting portion capable of binding and recruiting a nucleic acid editing entity naturally present in the cell. The nucleic acid editing entity, such as ADAR, is redirected to a preselected target site by means of the targeting portion, thereby promoting editing of preselected nucleotide residues in a region of the target RNA which corresponds to the targeting portion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.