Stabilisation and isolation of extracellular nucleic acids

US10676780B2 · kind B2 · utility

Assignee

• QIAGEN GmbH · DE

Inventors

• Martin Horlitz · Hilden, DE
• Annabelle Schubert · Hilden, DE
• Markus Sprenger-Haussels · Mettmann, DE

Key dates

• Filing date: Sep 25, 2012
• Grant date: Jun 9, 2020
• Expiry date: Feb 15, 2035

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2200/16
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides methods, compositions and devices for stabilizing the extracellular nucleic acid population in a cell-containing biological sample using an apoptosis inhibitor, preferably a caspase inhibitor, a hypertonic agent and/or a compound according to formula (1) as defined in the claims.