Translocation control for sensing by a nanopore
US10676782B2 · kind B2 · utility
1Cited by
4References
21Claims
0Family size
Assignee
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Key dates
| Filing date | Sep 12, 2019 |
| Grant date | Jun 9, 2020 |
| Priority date | — |
| Expiry date | Sep 12, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2565/631
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Translocation control for sensing by a nanopore, as well as methods and products related to the same, are provided. Such methods optimize duplex stability to provide high fill rate (of the hybridization sites) but do not prevent rapid dissociation required for high read rates, as well as controlling the translocation of a target molecule for sensing by a nanopore by use of a selective pulsed voltage. Products related to the same include a reporter construct comprising two or more phosphoramidites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.