Compound having mutant IDH inhibitory activity, preparation method and use thereof

US10682352B2 · kind B2 · utility

Assignees

• SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. · CN
• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Lei Jiang · Shanghai, CN
• Meiyu Geng · Shanghai, CN
• Qiangang Zheng · Shanghai, CN
• Min Huang · Chongqing, CN
• Huixin Wan · Nantong, CN
• Shuai Tang · Ibaraki, JP
• Xianlei FU · Shanghai, CN
• Xiaojing Lan · Shanghai, CN
• Jianhua Cao · Laishui, CN
• Feifei Liu · Shandong, CN
• Jian Ding · Shanghai, CN

Key dates

• Filing date: Mar 21, 2017
• Grant date: Jun 16, 2020
• Expiry date: Mar 21, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided in the present invention are a compound having the effects of preventing and treating diseases related to IDH mutation, and a preparation method and use thereof. In particular, provided in the present invention are the compound as shown in formula (I), a stereoisomer, a racemic body or a pharmaceutically acceptable salt thereof, and the use thereof in preparing drugs for preventing and treating diseases related to IDH mutation