Patent · US Active

Formulations for targeted release of agents under low pH conditions and methods of use thereof

US10682422B2 · kind B2 · utility

2Cited by

17References

17Claims

0Family size

Assignee

Yale University · US

Inventors

W. Mark Saltzman · New Haven, US
Junwei Zhang · Austin, US
Jiangbing Zhou · Cheshire, US
Zhaozhong Jiang · Edison, US

Key dates

Filing date	Nov 18, 2015
Grant date	Jun 16, 2020
Priority date	—
Expiry date	Apr 27, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Poly(amine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control or other transfection reagents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.