Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides
US10682423B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | May 25, 2018 |
| Grant date | Jun 16, 2020 |
| Priority date | — |
| Expiry date | May 25, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to antisense oligonucleotides (AONs) for modulating the expression of glycogen synthase. AONs of the present disclosure may be useful in treating diseases associated with the modulation of the expression of the enzyme glycogen synthase, such as Pompe disease. Also provided by the present disclosure are compositions comprising AONs, as well as methods of down regulating mRNA coding for glycogen synthase, methods for reducing glycogen synthase in skeletal and cardiac muscle, and methods for treating Pompe disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.