System and method for controlling outlet flow of a device for separating cellular suspensions
US10682611B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 12, 2018 |
| Grant date | Jun 16, 2020 |
| Priority date | — |
| Expiry date | Oct 7, 2038 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D2315/18
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.