Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof

US10683278B2 · kind B2 · utility

Assignees

• SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. · CN
• JINAN UNIVERSITY · CN
• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Ke Ding · 流花街道, CN
• Meiyu Geng · Shanghai, CN
• Li TAN · 流花街道, CN
• Jian Ding · Shanghai, CN
• Zhang Julia Zhang · Scotch Plains, US
• Jing Ai · Shanghai, CN
• Xiaomei REN · Tangxia, CN
• Donglin Gao · Tangxia, CN
• Zhengchao Tu · 流花街道, CN
• Xiaoyun Lu · 流花街道, CN
• Dongmei Zhang · 余新镇, CN

Key dates

• Filing date: Aug 18, 2016
• Grant date: Jun 16, 2020
• Expiry date: Aug 18, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.