Targeted protein degradation
US10683360B2 · kind B2 · utility
2Cited by
0References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 2, 2018 |
| Grant date | Jun 16, 2020 |
| Priority date | — |
| Expiry date | Jul 2, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/95
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a method of controlling the level of a polypeptide sequence comprising administering a polypeptide sequence fused to a ubiquitin targeting protein which comprises a minimal degron structural motif. In particular, the polypeptide sequence comprises a chimeric antigen receptor therefore the present invention is useful in methods of cell and gene therapy where the activity of the chimeric antigen receptor needs to be controlled.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.